Lisinopril Dihydrate

Name: Lisinopril Dihydrate
SKU: L3374
Availability: InStock

Product ID L3374

Cas No. 83915-83-7

Purity ≥98%

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Description

Lisinopril is an enalapril analog that inhibits angiotensin-converting enzyme (ACE), exhibiting antihypertensive, cardioprotective, and anti-fibrotic activities. Lisinopril is clinically used to treat hypertension, congestive heart failure (CHF), myocardial infarction, and retinal disorders associated with diabetes. In vivo, lisinopril decreases matrix metalloproteinase 2 (MMP2) activity, inhibits left ventricular dilation, and suppresses myocardial hypertrophy, preventing changes in contractility. In other animal models, this compound decreases hydroxyproline levels and inhibits paraquat-induced lung fibrosis.

Product Info

Cas No.	83915-83-7
Purity	≥98%
Formula	C₂₁H₃₁N₃O₅ • 2H₂O
Formula Wt.	441.52
Chemical Name	(S)-1-[N2-(1-Carboxy-3-phenylpropyl)-L-lysyl]- proline dihydrate
IUPAC Name	(2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl] pyrrolidine-2-carboxylic acid;dihydrate
Synonym	Acerbon, Carace, Coric, Novatec, Prinil, Tensopril, Vivatec, Zestril
Melting Point	160°C (dec)
Solubility	Soluble in water (100 mg/mL) or DMSO (6.5mg/mL with heating and sonication), methanol (14 mg/mL). Insoluble in ethanol.
Appearance	White or almost white crystalline powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	L3374 MSDS PDF
Info Sheet	L3374 Info Sheet PDF

References

Brower GL, Levick SP, Janicki JS. Inhibition of matrix metalloproteinase activity by ACE inhibitors prevents left ventricular remodeling in a rat model of heart failure. Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H3057-64. PMID: 17308006.

Mohammadi-Karakani A, Ghazi-Khansari M, Sotoudeh M. Lisinopril ameliorates paraquat-induced lung fibrosis. Clin Chim Acta. 2006 May;367(1-2):170-4. PMID: 16458281.

Goa KL, Balfour JA, Zuanetti G. Lisinopril. A review of its pharmacology and clinical efficacy in the early management of acute myocardial infarction. Drugs. 1996 Oct;52(4):564-88. PMID: 8891468.

Apostolakis S, Krambovitis E, Vlata Z, et al. CX3CR1 receptor is up-regulated in monocytes of coronary artery diseased patients: impact of pre-inflammatory stimuli and renin-angiotensin system modulators. Thromb Res. 2007;121(3):387-395. PMID: 17521710.

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Lisinopril Dihydrate

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Description

Product Info

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