LKT Labs

Biochemicals for Life Science Research

Lisinopril Dihydrate

Lisinopril Dihydrate

Product ID L3374
Cas No. 83915-83-7
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $72.00 In stock
1 g $143.00 In stock
5 g $350.00 In stock
Bulk Quote

Quicklinks

Description

Lisinopril is an enalapril analog that inhibits angiotensin-converting enzyme (ACE), exhibiting antihypertensive, cardioprotective, and anti-fibrotic activities. Lisinopril is clinically used to treat hypertension, congestive heart failure (CHF), myocardial infarction, and retinal disorders associated with diabetes. In vivo, lisinopril decreases matrix metalloproteinase 2 (MMP2) activity, inhibits left ventricular dilation, and suppresses myocardial hypertrophy, preventing changes in contractility. In other animal models, this compound decreases hydroxyproline levels and inhibits paraquat-induced lung fibrosis.

Product Info

Cas No.

83915-83-7
Purity

≥98%
Formula

C21H31N3O5 • 2H2O
Formula Wt.

441.52
Chemical Name

(S)-1-[N2-(1-Carboxy-3-phenylpropyl)-L-lysyl]- proline dihydrate
IUPAC Name

(2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl] pyrrolidine-2-carboxylic acid;dihydrate
Synonym

Acerbon, Carace, Coric, Novatec, Prinil, Tensopril, Vivatec, Zestril
Melting Point

160°C (dec)
Solubility

Soluble in water (100 mg/mL) or DMSO (6.5mg/mL with heating and sonication), methanol (14 mg/mL). Insoluble in ethanol.
Appearance

White or almost white crystalline powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

L3374 MSDS PDF
Info Sheet

L3374 Info Sheet PDF

References

Brower GL, Levick SP, Janicki JS. Inhibition of matrix metalloproteinase activity by ACE inhibitors prevents left ventricular remodeling in a rat model of heart failure. Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H3057-64. PMID: 17308006.

Mohammadi-Karakani A, Ghazi-Khansari M, Sotoudeh M. Lisinopril ameliorates paraquat-induced lung fibrosis. Clin Chim Acta. 2006 May;367(1-2):170-4. PMID: 16458281.

Goa KL, Balfour JA, Zuanetti G. Lisinopril. A review of its pharmacology and clinical efficacy in the early management of acute myocardial infarction. Drugs. 1996 Oct;52(4):564-88. PMID: 8891468.

Apostolakis S, Krambovitis E, Vlata Z, et al. CX3CR1 receptor is up-regulated in monocytes of coronary artery diseased patients: impact of pre-inflammatory stimuli and renin-angiotensin system modulators. Thromb Res. 2007;121(3):387-395. PMID: 17521710.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A0102

    A23187 Ca-Mg

    Ca2+ ionophore.

    ≥98%, TLC
  • N1755

    Neomycin Sulfate

    Polycationic aminoglycoside; protein translatio...

    ≥98%
  • B1652

    Benzo[a]pyrene

    Polycyclic aromatic hydrocarbon (PAH) found in ...

    ≥98%
  • G124088

    GDC-1971

    SHP2 inhibitor

    ≥99%
  • T5608

    α-Tocotrienol

    Antioxidant, vitamin E derivative found in vege...

    ≥98%
  • A0961

    Adrenocorticotropic Hormone (1-39), rat

    Endogenous peptide hormone, involved in stress ...

    ≥95%
  • T0253

    Tangeretin

    Polymethoxy flavonoid found in citrus fruits.

    ≥98%
  • I0416

    Iberin

    Isothiocyanate found in cruciferous vegetables,...

    ≥97%
  • M1777

    R-(−)-α-Methylbenzyl Isothiocyanate

    ITC, used as chiral agent.

    ≥98%
  • B1752

    Benidipine Hydrochloride

    Calcium channel blocker.

    ≥98%
  • B8248

    Bumetanide

    Loop diuretic; NKCC symporter and KCC2 co-trans...

    ≥98%
  • L302690

    LHRH Acetate Salt

    Endogenous peptide hormone, involved in secreti...

    ≥95%
  • P2510

    4-Phenylbutylisothiocyanate

    Synthetic ITC.

    ≥98%
  • I7478

    Istradefylline

    Adenosine A2A antagonist.

    ≥99%
  • S1604

    Secretin Acetate

    Endogenous peptide hormone, involved in feeding...

    ≥95%
  • B0396

    BAY80-6946

    p110α PI3K inhibitor.

    ≥98%
  • P0256

    Pantoprazole Sodium Sesquihydrate

    H+/K+ ATPase and ROCK-2 inhibitor.

    ≥98%
  • O2144

    Ofloxacin

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • T2970

    Thrombin Receptor Agonist Peptide

    Peptide; PAR1 agonist.

    ≥95%
  • C9609

    Cyclophosphamide Monohydrate

    Nitrogen mustard, DNA alkylator.

    ≥98%