• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Mdivi-1

Mdivi-1

Product ID M1335
Cas No. 338967-87-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $76.10 In stock
25 mg $303.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Mdivi-1 is a quinazolinone inhibitor of mitochondrial division that prevents mitochondrial fission and exhibits neuroprotective, cardioprotective, and anti-metastatic properties. In spinal cord injury models, Mdivi-1 decreases neuronal apoptosis and ameliorates motor dysfunction. In animal models of myocardial infarction, this compound decreases oxidative damage, enhances myocardial performance, and improves overall survival rates. Mdivi-1 also inhibits hypoxia-induced migration in breast cancer cells and improves the activity of other co-administered chemotherapeutics.

Product Info

Cas No.

338967-87-6

Purity

≥98%

Formula

C15H10Cl2N2O2S

Formula Wt.

353.2

Chemical Name

3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone

IUPAC Name

3-(2,4-Dichloro-5-methoxyphenyl)-2-thioxo-2,3-dihydro-4(1H)-quinazolinone

Solubility

DMSO 70 mg/mL Water Insoluble Ethanol Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M1335 MSDS PDF

Info Sheet

M1335 Info Sheet PDF

References

Li G, Jia Z, Cao Y, et al. Mitochondrial Division Inhibitor 1 Ameliorates Mitochondrial Injury, Apoptosis, and Motor Dysfunction After Acute Spinal Cord Injury in Rats. Neurochem Res. 2015 May 13. [Epub ahead of print]. PMID: 25968480.

Liu JM, Yi Z, Liu SZ, et al. The mitochondrial division inhibitor mdivi-1 attenuates spinal cord ischemia-reperfusion injury both in vitro and in vivo: Involvement of BK channels. Brain Res. 2015 Mar 24. [Epub ahead of print]. PMID: 25818100.

Sharp WW, Beiser DG, Fang YH, et al. Inhibition of the mitochondrial fission protein dynamin-related protein 1 improves survival in a murine cardiac arrest model. Crit Care Med. 2015 Feb;43(2):e38-47. PMID: 25599491.

Han XJ, Yang ZJ, Jiang LP, et al. Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells. Int J Oncol. 2015 Feb;46(2):691-700. PMID: 25434519.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • R1626

    Regorafenib Monohydrate

    VEGFR1/2/3, TIE2, PDGFRβ, FGFR1, c-Kit, RET, B...

    ≥99%
  • N1977

    Neurokinin A (4-10)

    Endogenous neuropeptide, also known as substanc...

    ≥95%
  • C5782

    Coumarin

    Benzopyrone found in various plants, precursor ...

    ≥98%
  • C3578

    L-Citrulline

    Byproduct of L-arginine metabolism found in wat...

    ≥98%
  • M1752

    Men 10376

    Peptide; NK2 antagonist.

    ≥95%
  • P327212

    Pifithrin-α-cyclic Hydrobromide

    p53 inhibitor

    ≥98%
  • P3441

    PIK-294

    p110δ PI3K inhibitor.

    ≥98%
  • A980005

    AZ-5104

    Inhibitor of EGFR.

    ≥98%
  • G720004

    GS-4997

    ASK1 inhibitor.

    ≥99%
  • R5212

    RN-486

    Btk inhibitor.

    ≥98%
  • A4441

    Allicin, aqueous solution

    Organosulfur found in garlic; Kir K+ channel ac...

    ≥98%
  • B6902

    B-Raf IN 1

    B-Raf and c-Raf inhibitor.

    ≥98%
  • A6828

    N(α),N(α)-Dimethyl-L-Arginine Ammonium

    Endogenous amino acid derivative, regulates water/...
    ≥98%
  • T5944

    Tolmetin Sodium

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • L8262

    Lupinine

    Alkaloid found in species of Loranthus, Calia, ...

    ≥98%
  • N1978

    Neurokinin B

    Neuromodulator, biomarker

    ≥95%
  • E543721

    Ensartinib

    A third-generation ALK inhibitor.

    ≥98%
  • O446185

    Oleuropein

    Bioactive compound from olive tree.

    ≥98%
  • G4782

    Glucoraphenin Potassium

    Glucosinolate found in cruciferous vegetables.<...

    ≥98%
  • D3261

    Dipropyl Disulfide

    Organosulfide found in Allium; cholesterol synt...

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only