LKT Labs

Biochemicals for Life Science Research

Mdivi-1

Mdivi-1

Product ID M1335
Cas No. 338967-87-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $76.10 In stock
25 mg $303.70 In stock
Bulk Quote

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Description

Mdivi-1 is a quinazolinone inhibitor of mitochondrial division that prevents mitochondrial fission and exhibits neuroprotective, cardioprotective, and anti-metastatic properties. In spinal cord injury models, Mdivi-1 decreases neuronal apoptosis and ameliorates motor dysfunction. In animal models of myocardial infarction, this compound decreases oxidative damage, enhances myocardial performance, and improves overall survival rates. Mdivi-1 also inhibits hypoxia-induced migration in breast cancer cells and improves the activity of other co-administered chemotherapeutics.

Product Info

Cas No.

338967-87-6
Purity

≥98%
Formula

C15H10Cl2N2O2S
Formula Wt.

353.2
Chemical Name

3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone
IUPAC Name

3-(2,4-Dichloro-5-methoxyphenyl)-2-thioxo-2,3-dihydro-4(1H)-quinazolinone
Solubility

DMSO 70 mg/mL Water Insoluble Ethanol Insoluble

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

M1335 MSDS PDF
Info Sheet

M1335 Info Sheet PDF

References

Li G, Jia Z, Cao Y, et al. Mitochondrial Division Inhibitor 1 Ameliorates Mitochondrial Injury, Apoptosis, and Motor Dysfunction After Acute Spinal Cord Injury in Rats. Neurochem Res. 2015 May 13. [Epub ahead of print]. PMID: 25968480.

Liu JM, Yi Z, Liu SZ, et al. The mitochondrial division inhibitor mdivi-1 attenuates spinal cord ischemia-reperfusion injury both in vitro and in vivo: Involvement of BK channels. Brain Res. 2015 Mar 24. [Epub ahead of print]. PMID: 25818100.

Sharp WW, Beiser DG, Fang YH, et al. Inhibition of the mitochondrial fission protein dynamin-related protein 1 improves survival in a murine cardiac arrest model. Crit Care Med. 2015 Feb;43(2):e38-47. PMID: 25599491.

Han XJ, Yang ZJ, Jiang LP, et al. Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cells. Int J Oncol. 2015 Feb;46(2):691-700. PMID: 25434519.

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