Description
Melphalan is a nitrogen mustard alkylator and a derivative of mechlorethamine. Melphalan exhibits anticancer chemotherapeutic activity, attaching alkyl groups to the N7 nitrogen of guanine bases on DNA, preventing DNA and RNA synthesis.
Melphalan is a nitrogen mustard alkylator and a derivative of mechlorethamine. Melphalan exhibits anticancer chemotherapeutic activity, attaching alkyl groups to the N7 nitrogen of guanine bases on DNA, preventing DNA and RNA synthesis.
Cas No. | 148-82-3 |
---|---|
Purity | ≥95% |
Formula | C13H18Cl2N2O2 |
Formula Wt. | 305.20 |
Chemical Name | 4-[Bis(2-chloroethyl)amino]-L-phenylalanine |
IUPAC Name | (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid |
Synonym | L-PAM, L-Phenylalanine mustard, L-Sarcolysine, Alkeran, Sarcoclorin |
Melting Point | 180-181°C |
Solubility | Soluble in ethanol or propylene glycol. Practically insoluble in water. |
Appearance | White to Yellow Powder |
Store Temp | 4°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Polavarapu A, Stillabower JA, Stubblefield SG, et al. The mechanism of guanine alkylation by nitrogen mustards: a computational study.
J Org Chem. 2012 Jul 20;77(14):5914-21. PMID: 22681226.
Falco P, Bringhen S, Avonto I, et al. Melphalan and its role in the management of patients with multiple myeloma.
Expert Rev Anticancer Ther. 2007 Jul;7(7):945-57. PMID: 17627453.
Nucleoside (deoxyguanosine) analog, ganciclovir...
Pyrrolopyrimidine; Akt inhibitor.
SERT and NET inhibitor, Nav1.7 Na+ channel bloc...
Non-proteinogenic amino acid, L-arginine metabo...
Flavanol originally found in Camilla (green tea...
Everolimus impurity
Endogenous peptide hormone; CCK2 agonist, indir...
Endogenous hormone and neurotransmitter involve...
Smoothened agonist.
NSAID; CB1 agonist, COX-2 inhibitor.
Mixture of taxanes.
Synthetic steroid, contraceptive; PR and glucoc...
Decreases expression of MMPs, PGE2, and COX-2, ...
RyR agonist, SIRT, telomerase, P2Y, GPCR inhibi...
Dual RAF/EGFR inhibitor.
Mycotoxin.
Carbapenem β-lactam; penicillin binding protei...
Endogenous organosulfur also found in meat and ...
ALK, c-Fes, LRRK2 inhibitor.
Endogenous steroid hormone involved in reproduc...