Description
Melphalan is a nitrogen mustard alkylator and a derivative of mechlorethamine. Melphalan exhibits anticancer chemotherapeutic activity, attaching alkyl groups to the N7 nitrogen of guanine bases on DNA, preventing DNA and RNA synthesis.
Melphalan
Product ID M1746
Cas No. 148-82-3
Purity ≥95%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 148-82-3 |
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| Purity | ≥95% |
| Formula | C13H18Cl2N2O2 |
| Formula Wt. | 305.20 |
| Chemical Name | 4-[Bis(2-chloroethyl)amino]-L-phenylalanine |
| IUPAC Name | (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid |
| Synonym | L-PAM, L-Phenylalanine mustard, L-Sarcolysine, Alkeran, Sarcoclorin |
| Melting Point | 180-181°C |
| Solubility | Soluble in ethanol or propylene glycol. Practically insoluble in water. DMSO 125 mg/mL. |
| Appearance | White to Yellow Powder |
Shipping and Storage
| Store Temp | 4°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Polavarapu A, Stillabower JA, Stubblefield SG, et al. The mechanism of guanine alkylation by nitrogen mustards: a computational study.
J Org Chem. 2012 Jul 20;77(14):5914-21. PMID: 22681226.
Falco P, Bringhen S, Avonto I, et al. Melphalan and its role in the management of patients with multiple myeloma.
Expert Rev Anticancer Ther. 2007 Jul;7(7):945-57. PMID: 17627453.