• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Nesiritide Acetate

Nesiritide Acetate

Product ID N1873
Cas No. 114471-18-0
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $173.30 In stock
1 mg $262.50 In stock
2.5 mg $472.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Nesiritide is recombinant B-type natriuretic peptide (BNP). BNP is often clinically used as a biomarker for cardiovascular problems like ventricular failure, stroke, and myocardial infarction. Nesiritide exhibits immunosuppressive, anti-inflammatory, and cardioprotective activities. Nesiritide exhibits mixed effects when administered clinically in the treatment of heart failure. Nesiritide decreases CD8+ T cells and levels of TNF-α, IL-1α, and IL-6. This peptide inhibits angiotensin II (ATII)-induced hypertrophy in animal models. Nesiritide suppresses generation of ROS, prevents decreases in the mitochondrial membrane potential, increases levels of Bcl-2, and decreases levels of Bax, inhibiting apoptosis and protecting cardiomyocytes against ischemia/reperfusion-induced injury. The additional diuretic, natriuretic, and vasorelaxant effects of nesiritide are mediated by its binding of the natriuretic peptide receptor A (guanylate cyclase A).

Product Info

Cas No.

114471-18-0

Purity

≥95%

Formula

C143H244N50O42S4

Formula Wt.

3464.1

Synonym

B-type natriuretic peptide, Brain natriuretic peptide, BNP, BNP-32 (human)

Solubility

Soluble in water, DMSO.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

N1873 Info Sheet PDF

References

Shaw SM, Critchley WR, Puchalka CM, et al. Brain natriuretic peptide induces CD8+ T cell death via a caspase 3 associated pathway--implications following heart transplantation. Transpl Immunol. 2012 Mar;26(2-3):119-22. PMID: 22138041.

Gassanov N, Biesenbach E, Caglayan E, et al. Natriuretic peptides in therapy for decompensated heart failure. Eur J Clin Pharmacol. 2012 Mar;68(3):223-30. PMID: 21901345.

Sun Y, Deng T, Lu N, et al. B-type natriuretic peptide protects cardiomyocytes at reperfusion via mitochondrial calcium uniporter. Biomed Pharmacother. 2010 Mar;64(3):170-6. PMID: 20149572.

Kishimoto I, Tokudome T, Horio T, et al. Natriuretic Peptide Signaling via Guanylyl Cyclase (GC)-A: An Endogenous Protective Mechanism of the Heart. Curr Cardiol Rev. 2009 Jan;5(1):45-51. PMID: 20066148.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T698579

    Tropodithietic Acid

    Produced by various marine proteobacteria

    ≥99%
  • I4800

    Imatinib free base

    Inhibitor of Abl, c-Kit, and PDGFR.

    ≥99%
  • E7433

    Etidronate Disodium

    Bisphosphonate, chelating agent.

    ≥98%
  • P2810

    Phenylbutazone

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • C0148

    Calcitonin, human

    Endogenous neuropeptide hormone, lowers extrace...

    ≥95%
  • G0243

    (−)-Gallocatechin

    Polyphenol found in Camilla sinensis; HIV integ...

    ≥98%
  • C9612

    Cyclosporin C

    Cyclosporin metabolite; weak calmodulin inhibit...

    ≥98%
  • R7680

    Recombinant M. Tuberculosis Antigen TB 38+6+10

    Tuberculosis antigen

  • M568264

    Mogroside IIe

    Triterpenoid

    ≥98%
  • S1843

    L-Selectin

    Endogenous adhesion molecule, binds PKC, calmod...

    ≥95%
  • Z5645

    Zoledronate Disodium Tetrahydrate

    Bisphosphonate; FPPS inhibitor.

    ≥98%
  • T0394

    (+)-Taxifolin

    Catechol-type flavonoid; fatty acid synthesis i...

    ≥98%
  • M184776

    5-(Methylsulfonyl)pentyl Nitrile

    Synthetic nitrile compound

    ≥98%
  • I7447

    1-Isothiocyanato-6-(methylsulfenyl)-hexane

    Synthetic ITC, erucin analog.

    ≥98%
  • X1854

    p-Xyleneselenocyanate

    Synthetic derivative of selenocyanate.

    ≥99%
  • C0169

    Carbenoxolone Disodium

    Synthetic derivative of glycyrrhizin; connexin ...

    ≥97%
  • B3211

    (+)-Bicuculline

    NMDA potentiator, GABA-A antagonist.

    ≥98%
  • U5232

    Uniconazole

    Triazole; gibberellin inhibitor, potential 14-Î...

    ≥98%
  • M0126

    Magainin 2

    Antimicrobial peptide found in frogs, induces p...

    ≥95%
  • S8243

    Sulbactam Sodium

    β-lactamase inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only