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Nesiritide Acetate

Nesiritide Acetate

Product ID N1873
Cas No. 114471-18-0
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $173.30 In stock
1 mg $262.50 In stock
2.5 mg $472.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Nesiritide is recombinant B-type natriuretic peptide (BNP). BNP is often clinically used as a biomarker for cardiovascular problems like ventricular failure, stroke, and myocardial infarction. Nesiritide exhibits immunosuppressive, anti-inflammatory, and cardioprotective activities. Nesiritide exhibits mixed effects when administered clinically in the treatment of heart failure. Nesiritide decreases CD8+ T cells and levels of TNF-α, IL-1α, and IL-6. This peptide inhibits angiotensin II (ATII)-induced hypertrophy in animal models. Nesiritide suppresses generation of ROS, prevents decreases in the mitochondrial membrane potential, increases levels of Bcl-2, and decreases levels of Bax, inhibiting apoptosis and protecting cardiomyocytes against ischemia/reperfusion-induced injury. The additional diuretic, natriuretic, and vasorelaxant effects of nesiritide are mediated by its binding of the natriuretic peptide receptor A (guanylate cyclase A).

Product Info

Cas No.

114471-18-0

Purity

≥95%

Formula

C143H244N50O42S4

Formula Wt.

3464.1

Synonym

B-type natriuretic peptide, Brain natriuretic peptide, BNP, BNP-32 (human)

Solubility

Soluble in water, DMSO.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

N1873 Info Sheet PDF

References

Shaw SM, Critchley WR, Puchalka CM, et al. Brain natriuretic peptide induces CD8+ T cell death via a caspase 3 associated pathway--implications following heart transplantation. Transpl Immunol. 2012 Mar;26(2-3):119-22. PMID: 22138041.

Gassanov N, Biesenbach E, Caglayan E, et al. Natriuretic peptides in therapy for decompensated heart failure. Eur J Clin Pharmacol. 2012 Mar;68(3):223-30. PMID: 21901345.

Sun Y, Deng T, Lu N, et al. B-type natriuretic peptide protects cardiomyocytes at reperfusion via mitochondrial calcium uniporter. Biomed Pharmacother. 2010 Mar;64(3):170-6. PMID: 20149572.

Kishimoto I, Tokudome T, Horio T, et al. Natriuretic Peptide Signaling via Guanylyl Cyclase (GC)-A: An Endogenous Protective Mechanism of the Heart. Curr Cardiol Rev. 2009 Jan;5(1):45-51. PMID: 20066148.

Custom Order

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