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[Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone

[Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone

Product ID M7530
Cas No. 75921-69-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $52.50 In stock
2.5 mg $105.00 In stock
5 mg $210.00 In stock
25 mg $840.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
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Description

Melanotan-I (NDP-MSH) is a semi-synthetic melanocortin analog that activates the melanocortin receptor. NDP-MSH exhibits both pro-inflammatory and anti-inflammatory activities in various models. In animal models of liver regeneration, NDP-MSH increases levels of IL-6, promotes signaling by STAT and SOCS, and inhibits the decline in IκBα levels. In animal models of peritonitis, NDP-MSH decreases neutrophil trafficking and inhibits vascular leakage and leukocyte rolling and adhesion. Additionally, NDP-MSH inhibits subarachnoid hemorrhage-induced stress, inflammation, vascular remodeling, and apoptosis in other animal models.

Product Info

Cas No.

75921-69-6

Purity

≥98%

Formula

C78H111N21O19

Formula Wt.

1646.9

Synonym

NDP-MSH, Melanotan I, afamelanotide

Solubility

Soluble in water (0.6 mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M7530 MSDS PDF

Info Sheet

M7530 Info Sheet PDF

References

Lonati C, Carlin A, Leonardi P, et al. Modulatory effects of NDP-MSH in the regenerating liver after partial hepatectomy in rats. Peptides. 2013 Dec;50:145-52. PMID: 24446557.

Figueiredo J, Ferreira AE, Silva RL, et al. NDP-MSH inhibits neutrophil migration through nicotinic and adrenergic receptors in experimental peritonitis. Naunyn Schmiedebergs Arch Pharmacol. 2013 Apr;386(4):311-8. PMID: 23338711.

Gatti S, Lonati C, Acerbi F, et al. Protective action of NDP-MSH in experimental subarachnoid hemorrhage. Exp Neurol. 2012 Mar;234(1):230-8. PMID: 22230666.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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