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Ofloxacin

Ofloxacin

Product ID O2144
Cas No. 82419-36-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $75.10 In stock
10 g $135.10 In stock
50 g $525.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Ofloxacin is a second generation fluoroquinolone antibiotic. This compound is often given as a topical treatment for ocular and otic infections. Like other fluoroquinolones, ofloxacin inhibits DNA gyrase and topoisomerase IV; it exhibits antibacterial efficacy against both gram positive and gram negative bacteria. Under UV light, ofloxacin exhibits phototoxicity, disputing the mitochondrial membrane potential and inducing ROS-mediated DNA damage.

Product Info

Cas No.

82419-36-1

Purity

≥98%

Formula

C18H20FN3O4

Formula Wt.

361.37

Chemical Name

7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 2,3- dihydro-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo- , (+-)-

IUPAC Name

7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid

Synonym

Floxin, Ofloxacin,Tarivid

Melting Point

250-257°C (dec.)

Solubility

Slightly soluble in water, DMSO, methanol, chloroform. Soluble in 1M NaOH (50 mg/mL).

Appearance

Off White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

O2144 MSDS PDF

Info Sheet

O2144 Info Sheet PDF

References

Dwivedi A, Mujtaba SF, Yadav N, et al. Cellular and molecular mechanism of ofloxacin induced apoptotic cell death under ambient UV-A and sunlight exposure. Free Radic Res. 2014 Mar;48(3):333-46. PMID: 24286391.

Pantel A, Petrella S, Matrat S, et al. DNA gyrase inhibition assays are necessary to demonstrate fluoroquinolone resistance secondary to gyrB mutations in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2011 Oct;55(10):4524-9. PMID: 21768507.

Drlica K, Zhao X. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. PMID: 9293187.

Custom Order

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