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P75-TNFR is a peptide fragment of the P75 tumor necrosis factor (TNF) receptor. This receptor is involved in post-injury protective signaling and mediates expression of plasminogen activator inhibitor 1 (PAI-1). The P75-TNFR also modulates signaling of inflammatory cytokines.
| Purity | ≥95% |
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| Formula | C53H85N15O15S |
| Formula Wt. | 1204.42 |
| Synonym | TNFR-II |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| Info Sheet |
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Pandey M, Tuncman G, Hotamisligil GS, et al. Divergent roles for p55 and p75 TNF-alpha receptors in the induction of plasminogen activator inhibitor-1. Am J Pathol. 2003 Mar;162(3):933-41. PMID: 12598326.
Shen Y, Li R, Shiosaki K. Inhibition of p75 tumor necrosis factor receptor by antisense oligonucleotides increases hypoxic injury and beta-amyloid toxicity in human neuronal cell line. J Biol Chem. 1997 Feb 7;272(6):3550-3. PMID: 9013604.