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SB-590885

SB-590885

Product ID S0459
Cas No. 405554-55-4
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $71.50 In stock
5 mg $214.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

SB-590885 is a triarylimidazole that selectively inhibits Raf kinase and is a particularly potent inhibitor of B-Raf. SB-590885 exhibits anticancer chemotherapeutic activity through its ability to stabilize the oncogenic B-Raf kinase domain in an active configuration, therefore inhibiting downstream MAPK activation. SB-590885 also limits tissue damage after cerebral ischemia, displaying neuroprotective benefit.

Product Info

Cas No.

405554-55-4

Purity

≥97%

Formula

C27H27N5O2

Formula Wt.

453.54

Chemical Name

(E)-5-(2-(4-(2-(dimethylamino)ethoxy)phenyl)-4-(pyridin-4-yl)-1H-imidazol-5-yl)-2,3-dihydroinden-1-one oxime

IUPAC Name

N,N-dimethyl-2-[4-[(4Z)-4-(1-nitroso-2, 3-dihydroinden-5-ylidene)-5-(1H-pyridin-4-ylidene)-1H-imidazol-2-yl] phenoxy]ethanamine

Solubility

DMSO 5 mg/mL (11.02 mM) Water Insoluble Ethanol Insoluble

Appearance

Light yellow solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S0459 MSDS PDF

Info Sheet

S0459 Info Sheet PDF

Brochures

Ras-Raf-MEK-ERK Pathway Booklet

References

Ahnstedt H, Säveland H, Nilsson O, et al. Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK-sensitive signaling pathway. BMC Neurosci. 2011 Jan 11;12:5. PMID: 21223556.

King AJ, Patrick DR, Batorsky RS, et al. Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res. 2006 Dec 1;66(23):11100-5. PMID: 17145850.

Custom Order

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  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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