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Sorafenib Tosylate

Sorafenib Tosylate

Product ID S5869
Cas No. 475207-59-1
Purity ≥99%
Product Unit SizeCostQuantityStock
25 mg $67.60 In stock
100 mg $220.20 In stock
250 mg $392.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Sorafenib is an inhibitor of c-Raf, RET, and VEGFR2 that is currently used clinically to treat renal cell carcinoma and hepatocellular carcinoma, as well as other advanced cancers. Sorafenib exhibits anticancer chemotherapeutic, anti-angiogenic, and immunosuppressive activities. In osteosarcoma cells, sorafenib inhibits cell proliferation by downregulating expression of ERK and VEGFR2 and inhibiting phosphorylation of VEGFR2, RET, and MEK1. In cellular and animal models of lymphoma, sorafenib inhibits phosphorylation of MAPKs and PI3K/Akt, decreasing vessel density and increasing apoptotic cell death. Sorafenib also inhibits the epithelial-to-mesenchymal transition (EMT) in epithelial cells and potentiates histone acetylation. In hepatoma cells, this compound decreases levels of enhancer of zeste homolog 2 (EZH2) and inhibits histone methyltransferase (HMT) activity, inducing apoptosis. In animal models, sorafenib inhibits tumor growth, increases tumor-specific T cells, and decreases CD8+ and Treg T cell functions by inducing T cell apoptosis. Additionally, sorafenib inhibits phosphorylation of STAT3/5.

Product Info

Cas No.

475207-59-1

Purity

≥99%

Formula

C21H16ClF3N4O3 C7H8O3S

Formula Wt.

637.03

IUPAC Name

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N- methylpyridine-2-carboxamide;4-methylbenzenesulfonic acid

Synonym

Nexavar

Melting Point

225-228°C

Solubility

DMSO 200 mg/mL

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

S5869 MSDS PDF

Info Sheet

S5869 Info Sheet PDF

References

Vin H, Ching G, Ojeda S, et al. Sorafenib suppresses JNK-dependent apoptosis through inhibition of ZAK. Mol Cancer Ther. 2013 Oct 29. [Epub ahead of print]. PMID: 24170769.

Chen ML, Yan BS, Lu WC, et al. Sorafenib relieves cell-intrinsic and cell-extrinsic inhibitions of effector T cells in tumor microenvironment to augment antitumor immunity. Int J Cancer. 2013 Jul 2. [Epub ahead of print]. PMID: 23818246.

Zhang J, Chen YL, Ji G, et al. Sorafenib inhibits epithelial-mesenchymal transition through an epigenetic-based mechanism in human lung epithelial cells. PLoS One. 2013 May 31;8(5):e64954. PMID: 23741434.

Wang S, Zhu Y, He H, et al. Sorafenib suppresses growth and survival of hepatoma cells by accelerating degradation of enhancer of zeste homolog 2. Cancer Sci. 2013 Jun;104(6):750-9. PMID: 23421437.

Mao WF, Shao MH, Gao PT, et al. The important roles of RET, VEGFR2 and the RAF/MEK/ERK pathway in cancer treatment with sorafenib. Acta Pharmacol Sin. 2012 Oct;33(10):1311-8. PMID: 22941289.

Liu LP, Ho RL, Chen GG, et al. Sorafenib inhibits hypoxia-inducible factor-1α synthesis: implications for antiangiogenic activity in hepatocellular carcinoma. Clin Cancer Res. 2012 Oct 15;18(20):5662-71. PMID: 22929805.

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