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Theophylline is a methylxanthine compound that exhibits bronchodilatory, anti-asthma, anti-tussive, and anti-inflammatory activities. Theophylline is clinically used to treat respiratory diseases such as chronic obstructive pulmonary disorder (COPD), asthma, and cough. Theophylline is a nonselective inhibitor of phosphodiesterases (PDEs), increasing cAMP levels and PKA activation; it also inhibits adenosine A1/2 receptors.
| Cas No. | 58-55-9 |
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| Purity | ≥98% |
| Formula | C7H8N4O2 |
| Formula Wt. | 180.16 |
| Chemical Name | 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione |
| IUPAC Name | 1,3-dimethyl-7H-purine-2,6-dione |
| Synonym | Theophylline anhydrous, 1,3-Dimethylxanthine, Diphyllin, Elixicon, Sustaire |
| Melting Point | 271-273°C |
| Solubility | Slightly soluble in water (4 mg/mL). Soluble in ammonium hydroxide (50 mg/mL), alcohol (10 mg/mL), DMSO (15 mg/mL). |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Dubuis E, Wortley MA, Grace MS, et al. Theophylline inhibits the cough reflex through a novel mechanism of action. J Allergy Clin Immunol. 2014 Jun;133(6):1588-98. PMID: 24406072.
Barnes PJ. Theophylline. Am J Respir Crit Care Med. 2013 Oct 15;188(8):901-6. PMID: 23672674.
Essayan DM. Cyclic nucleotide phosphodiesterases. J Allergy Clin Immunol. 2001 Nov;108(5):671-80. PMID: 11692087.
Daly JW, Jacobson KA, Ukena D. Adenosine receptors: development of selective agonists and antagonists. Prog Clin Biol Res. 1987;230:41-63. PMID: 3588607.