• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Wogonin

Wogonin

Product ID W5726
Cas No. 632-85-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $183.10 In stock
10 mg $276.30 In stock
25 mg $619.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Wogonin is a plant flavonoid originally found in species of Scutellaria. Wogonin exhibits anticancer chemotherapeutic, anti-inflammatory, and anti-angiogenic activities. In lung adenocarcinoma cells, wogonin downregulates expression of c-Myc, SKP2, HDAC1/2, and GSK-3β, inducing apoptosis. In other cancer cell lines, this compound inhibits cyclin-dependent kinase 9 (CDK9) and downregulates expression of anti-apoptotic protein Mcl-1, also inducing apoptosis. In animal models of colon cancer, wogonin downregulates expression of HIF-1α and PI3K/Akt and inhibits tumor growth. In endothelial cells, wogonin inhibits phosphorylation of VEGFR2, ERK, Akt, and p38 MAPK, preventing cell migration and tube formation. Additionally, wogonin also inhibits expression of iNOS and COX-2 across various cell lines.

Product Info

Cas No.

632-85-9

Purity

≥98%

Formula

C16H12O5

Formula Wt.

284.26

IUPAC Name

5,7-dihydroxy-8-methoxy-2-phenylchromen-4-one

Synonym

5,7-Dihydroxy-8-methoxyflavone

Melting Point

202-206°C

Solubility

≥20 mg/ml in DMSO. 1 mg/ml in ethanol. Insoluble in water.

Appearance

Yellow Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

W5726 MSDS PDF

Info Sheet

W5726 Info Sheet PDF

References

Chen XM, Bai Y, Zhong YJ, et al. Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549. PLoS One. 2013 Nov 12;8(11):e79201. PMID: 24265759.

Wang H, Zhao L, Zhu LT, et al. Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway. Mol Carcinog. 2013 Jun 13. [Epub ahead of print]. PMID: 23761018.

Polier G, Ding J, Konkimalla BV, et al. Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. Cell Death Dis. 2011 Jul 21;2:e182. PMID: 21776020

Lu N, Gao Y, Ling Y, et al. Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2. Life Sci. 2008 Apr 23;82(17-18):956-63. PMID: 18378261.

Wakabayashi I. Inhibitory effects of baicalein and wogonin on lipopolysaccharide-induced nitric oxide production in macrophages. Pharmacol Toxicol. 1999 Jun;84(6):288-91. PMID: 10401731.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A4002

    AK-7

    SIRT2 inhibitor.

    ≥98%
  • S2957

    Shogaol

    Phenol found in Zingiber; PPARγ agonist, 5-HT3...

    ≥98%
  • M1678

    2-Methoxyestradiol

    Estradiol metabolite; microtubule depolymerizat...

    ≥98%
  • P337538

    (-)-Pinostrobin

    Neuroprotective flavonoid

    ≥99%
  • H5748

    D,L-Homocysteine Thiolactone Hydrochloride

    Heterocyclic derivative of cysteine, alters pro...

    ≥99%
  • D564090

    7-epi-Docetaxel

    Docetaxel impurity

    ≥95%
  • P2512

    S-(N-Phenethylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, antioxidant.

    ≥98%
  • K0023

    K252c

    Staurosporine analog; PKC and PKA inhibitor.

    ≥98%
  • D0032

    Daidzein

    Phytoestrogen, isoflavone found in various plan...

    ≥97%
  • A0971

    Adrenocorticotropic Hormone (4-10), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • O6953

    Ornidazole

    5-Nitroimidazole derivative; genotoxic.

    ≥98%
  • F1669

    Ferulic Acid

    Hydroxycinnamic acid found in various plant sou...

    ≥98%
  • A5285

    [Ile7]-Angiotensin III

    Peptide, derivative of AT III, cleavage product...

    ≥95%
  • A1368

    Adrenomedullin (1-52), human

    Endogenous peptide hormone, involved in cell gr...

    ≥95%
  • S8045

    S-Sulforaphane

    Synthetic antioxidant that induces phase II enz...

    ≥96%
  • J3204

    E-JIB-04

    Jumonji histone demethylase inhibitor.

    ≥98%
  • E2003

    Efavirenz

    Non-nucleoside RT inhibitor.

    ≥99%
  • B3320

    Bifonazole

    Imidazole; HMG-CoA reductase, 14-α demethylase...

    ≥98%
  • A7462

    Aspartame

    Dipeptide ester, commercial sweetener.

    ≥98%
  • P5745

    Polygalic Acid

    Saponin found in Polygala.

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only