Furosemide

Name: Furosemide
SKU: F8270
Availability: InStock

Product ID F8270

Cas No. 54-31-9

Purity ≥97%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Furosemide is a loop diuretic that is clinically used to treat congestive heart failure, edema, and hypertension; it inhibits the Na+/K+/Cl2- (NKCC) symporter and CFTR Cl- channels in the loop of Henle, decreasing reabsorption of Na+ and K+ and increasing secretion of Mg2+ and Ca2+. Furosemide exhibits antihypertensive, anxiolytic, and potentially antiepileptic/anticonvulsant activities. Furosemide noncompetitively inhibits GABA-A receptors and decreases conditioned anxiety in animal models of contextual fear conditioning and fear-potentiated startle.

Product Info

Cas No.	54-31-9
Purity	≥97%
Formula	C₁₂H₁₁ClN₂O₅S
Formula Wt.	330.74
Chemical Name	5-(Aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)- amino]benzoic acid
IUPAC Name	4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid
Synonym	Fursemide, Beronald, Discoid, Durafurid, Eutensin, Fulsix, Furosedon, Impugan, Katlex, Lasix, Macasirrol, Nicorol, Odemase, Rosemide, Urex
Melting Point	203-206°C
Solubility	Soluble in acetone, DMF, and methanol. Slightly soluble in water, chloroform and ether.
Appearance	Cream/ Off-White powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	F8270 MSDS PDF
Info Sheet	F8270 Info Sheet PDF

References

Ju M, Scott-Ward TS, Liu J, et al. Loop diuretics are open-channel blockers of the cystic fibrosis transmembrane conductance regulator with distinct kinetics. Br J Pharmacol. 2014 Jan;171(1):265-78. PMID: 24117047.

Krystal AD, Sutherland J, Hochman DW. Loop diuretics have anxiolytic effects in rat models of conditioned anxiety. PLoS One. 2012;7(4):e35417. PMID: 22514741.

Somasekharan S, Tanis J, Forbush B. Loop diuretic and ion-binding residues revealed by scanning mutagenesis of transmembrane helix 3 (TM3) of Na-K-Cl cotransporter (NKCC1). J Biol Chem. 2012 May 18;287(21):17308-17. PMID: 22437837.

Korpi ER, Kuner T, Seeburg PH, et al. Selective antagonist for the cerebellar granule cell-specific gamma-aminobutyric acid type A receptor. Mol Pharmacol. 1995 Feb;47(2):283-9. PMID: 7870036.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Comments
This field is for validation purposes and should be left unchanged.

Furosemide

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Polygalic Acid

Ibudilast

Parasin I

Tyrphostin AG1295

Dapivirine

Icariin

S-(−)-Schisandrin B

1-Isothiocyanato-8-(methylsulfonyl)-octane

Adrenocorticotropic Hormone (1-10), human

SB-202190

Clinafloxacin Hydrochloride

Glucagon (19-29), human

Dehydrocorydaline

Nicotinamide

C-171

Tofacitinib Citrate

(±)-Equol

A23187 Ca-Mg

AG-1024

Pifithrin-α Hydrobromide

Footer