Description
P7C3 is an aminopropyl carbazole that displays neuroprotective, antidepressant, and cognition enhancing activities, particularly in models of Parkinson’s disease and amyotrophic lateral sclerosis (ALS). P7C3 promotes neurogenesis in vivo in the hippocampal dentate gyrus, preventing neuron apoptosis in newborn mice, and also prevents neuron death and cognitive decline in aged mice. P7C3 rescues TGF-β ligand mutation-induced retinal apoptosis in vivo. In C. elegans models, this compound inhibits MPP+-mediated death of dopaminergic neurons. Also, when given prior to expected symptom onset, P7C3 delays disease progression in animal models of ALS.