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α-Conotoxin IMI is a peptide inhibitor of α7 nicotinic acetylcholine receptors (nAChRs) originally found in species of Conus snails. α-Conotoxin IMI disrupts motor coordination, inhibiting the swimming ability of leeches. Like other conotoxins, α-conotoxin IMI binds the interface between different subunits of nAChRs.
| Cas No. | 156467-85-5 |
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| Purity | ≥95% |
| Formula | C52H78N20O15S4 |
| Formula Wt. | 1351.56 |
| Solubility | Soluble in 20% acetonitrile (1 mg/mL). |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Yu R, Craik DJ, Kaas Q. Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations. PLoS Comput Biol. 2011 Mar;7(3):e1002011. PMID: 21390272.
Wagenaar DA, Gonzalez R, Ries DC, et al. Alpha-conotoxin ImI disrupts central control of swimming in the medicinal leech. Neurosci Lett. 2010 Nov 26;485(3):151-6. PMID: 20833225.
Ellison M, McIntosh JM, Olivera BM. Alpha-conotoxins ImI and ImII. Similar alpha 7 nicotinic receptor antagonists act at different sites. J Biol Chem. 2003 Jan 10;278(2):757-64. PMID: 12384509.