LKT Labs

Biochemicals for Life Science Research

AMI-1 Sodium

Product ID A491321
Cas No. 20324-87-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $96.50 Please Inquire
25 mg $395.60 Please Inquire
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Description

Arginine N-Methyltransferase Inhibitor-1, also known as AMI-1, is an inhibitor of protein arginine methyltransferases (PRMTs). PRMTs are a class of epigenetic modified enzymes that are overexpressed in some cancers, responsible for key functions in tumor development. It has shown antiproliferative effects in both mouse sarcoma 180 and human osteosarcoma U2OS cells. It inhibits gastric cancer, possibly through the downregulation of eukaryotic translation initiation factor 4E and the targeting of type II PRMT5.

Product Info

Cas No.

20324-87-2
Purity

≥98%
Formula

C21H14N2Na2O9S2
Formula Wt.

548.45
Chemical Name

Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
IUPAC Name

disodium;4-hydroxy-7-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)carbamoylamino]naphthalene-2-sulfonate
Synonym

W-107632; AMI 1 sodium; 2-Naphthalenesulfonic acid, 7,7'-(carbonyldiimino)bis(4-hydroxy-, sodium salt (1:2)

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

A491321 MSDS PDF
Info Sheet

A491321 Info Sheet PDF

References

Zhang B., Chen X., et al. Arginine methyltransferase inhibitor-1 inhibits sarcoma viability in vitro and in vivo. Oncol Lett. 16(2):2161-66 (2018). PMID: 30008914.

Zhang B., Zhang S., et al. Arginine methyltransferase inhibitor 1 inhibits gastric cancer by downregulating eIF4E and targeting PRMT5. Toxicol Appl Pharmacol. 336:1-7 (2017). PMID: 28987382.

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