| Product Unit Size | Cost | Quantity | Stock |
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KT 5720 is an inhibitor of PKA. KT5720 attenuates hyperpolarization-activated cyclic nucleotide-gated (HCN) channel currents, decreasing amplitude and increasing action potential threshold. This inhibition results in decreases in intracellular Ca2+ levels and suppression of dorsal root ganglion (DRG) neuron excitability. This compound also inhibits PDK1 and may inhibit GSK-3, MEK, MSK1, and PKB.
| Cas No. | 108068-98-0 |
|---|---|
| Purity | ≥98% |
| Formula | C32H31N3O5 |
| Formula Wt. | 537.23 |
| IUPAC Name | hexyl (15R,16S,18S)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylate |
| Solubility | Soluble in methanol, DMSO |
| Appearance | White Powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Iwase K, Ishihara A, Yoshimura S, et al. The secretogranin II gene is a signal integrator of glutamate and dopamine inputs. J Neurochem. 2014 Jan;128(2):233-45. PMID: 24111984.
Hoffman MS, Mitchell GS. Spinal 5-HT7 receptors and protein kinase A constrain intermittent hypoxia-induced phrenic long-term facilitation. Neuroscience. 2013 Oct 10;250:632-43. PMID: 23850591.
Cheng Q, Zhou Y. Novel role of KT5720 on regulating hyperpolarization-activated cyclic nucleotide-gated channel activity and dorsal root ganglion neuron excitability. DNA Cell Biol. 2013 Jun;32(6):320-8. PMID: 23713946.