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Nitidine Chloride

Nitidine Chloride

Product ID N3577
Cas No. 13063-04-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $91.00 In stock
5 mg $145.80 Please Inquire
25 mg $592.50 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Nitidine is a benzophenanthridine alkaloid that exhibits anticancer chemotherapeutic, anti-inflammatory, anti-parasitic, and antifungal properties. In cancer cells, nitidine decreases phosphorylation of Akt and downregulates expression of matrix metalloproteinases 2 and 9 (MMP2/9), inhibiting cellular migration and invasion. In vivo, nitidine inhibits activation of JAK/STAT3, downregulates expression of cyclin D1, cyclin-dependent kinase 4 (CDK4), and Bcl-2, and upregulates expression of p21 and Bax, resulting in decreases in tumor weight and volume. Additionally, nitidine inhibits topoisomerase I and binds to DNA sequences containing alternating G and C base pairs. In macrophages, this compound decreases production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 and inhibits phosphorylation of MAPK and activation of NF-κB. Nitidine also displays inhibitory activity against species of Plasmodium that are resistant to chloroquine and other antimalarial compounds.

Product Info

Cas No.

13063-04-2

Purity

≥98%

Formula

C21H18ClNO4

Formula Wt.

383.82

IUPAC Name

2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride

Solubility

1mg/ml in DMSO

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

N3577 MSDS PDF

Info Sheet

N3577 Info Sheet PDF

References

Fang Z, Tang Y, Jiao W, et al. Nitidine chloride inhibits renal cancer cell metastasis via suppressing AKT signaling pathway. Food Chem Toxicol. 2013 Oct;60:246-51. PMID: 23911800.

Liao J, Xu T, Zheng JX, et al. Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1/STAT3 signaling pathway. Int J Mol Med. 2013 Jul;32(1):79-84. PMID: 23613111.

Wang Z, Jiang W, Zhang Z, et al. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells. J Ethnopharmacol. 2012 Oct 31;144(1):145-50. PMID: 22971898.

Bai LP, Zhao ZZ, Cai Z, et al. DNA-binding affinities and sequence selectivity of quaternary benzophenanthridine alkaloids sanguinarine, chelerythrine, and nitidine. Bioorg Med Chem. 2006 Aug 15;14(16):5439-45. PMID: 16730995.

Nyangulu JM, Hargreaves SL, Sharples SL, et al. Antimalarial benzo[c]phenanthridines. Bioorg Med Chem Lett. 2005 Apr 15;15(8):2007-10. PMID: 15808457.

Li D, Zhao B, Sim SP, et al. 2,3-Dimethoxybenzo[i]phenanthridines: topoisomerase I-targeting anticancer agents. Bioorg Med Chem. 2003 Feb 20;11(4):521-8. PMID: 12538017.

Del Poeta M, Chen SF, Von Hoff D, et al. Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells. Antimicrob Agents Chemother. 1999 Dec;43(12):2862-8. PMID: 10582872.

Custom Order

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