• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Nitidine Chloride

Nitidine Chloride

Product ID N3577
Cas No. 13063-04-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $91.00 In stock
5 mg $145.80 Please Inquire
25 mg $592.50 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Nitidine is a benzophenanthridine alkaloid that exhibits anticancer chemotherapeutic, anti-inflammatory, anti-parasitic, and antifungal properties. In cancer cells, nitidine decreases phosphorylation of Akt and downregulates expression of matrix metalloproteinases 2 and 9 (MMP2/9), inhibiting cellular migration and invasion. In vivo, nitidine inhibits activation of JAK/STAT3, downregulates expression of cyclin D1, cyclin-dependent kinase 4 (CDK4), and Bcl-2, and upregulates expression of p21 and Bax, resulting in decreases in tumor weight and volume. Additionally, nitidine inhibits topoisomerase I and binds to DNA sequences containing alternating G and C base pairs. In macrophages, this compound decreases production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 and inhibits phosphorylation of MAPK and activation of NF-κB. Nitidine also displays inhibitory activity against species of Plasmodium that are resistant to chloroquine and other antimalarial compounds.

Product Info

Cas No.

13063-04-2

Purity

≥98%

Formula

C21H18ClNO4

Formula Wt.

383.82

IUPAC Name

2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride

Solubility

1mg/ml in DMSO

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

N3577 MSDS PDF

Info Sheet

N3577 Info Sheet PDF

References

Fang Z, Tang Y, Jiao W, et al. Nitidine chloride inhibits renal cancer cell metastasis via suppressing AKT signaling pathway. Food Chem Toxicol. 2013 Oct;60:246-51. PMID: 23911800.

Liao J, Xu T, Zheng JX, et al. Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1/STAT3 signaling pathway. Int J Mol Med. 2013 Jul;32(1):79-84. PMID: 23613111.

Wang Z, Jiang W, Zhang Z, et al. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells. J Ethnopharmacol. 2012 Oct 31;144(1):145-50. PMID: 22971898.

Bai LP, Zhao ZZ, Cai Z, et al. DNA-binding affinities and sequence selectivity of quaternary benzophenanthridine alkaloids sanguinarine, chelerythrine, and nitidine. Bioorg Med Chem. 2006 Aug 15;14(16):5439-45. PMID: 16730995.

Nyangulu JM, Hargreaves SL, Sharples SL, et al. Antimalarial benzo[c]phenanthridines. Bioorg Med Chem Lett. 2005 Apr 15;15(8):2007-10. PMID: 15808457.

Li D, Zhao B, Sim SP, et al. 2,3-Dimethoxybenzo[i]phenanthridines: topoisomerase I-targeting anticancer agents. Bioorg Med Chem. 2003 Feb 20;11(4):521-8. PMID: 12538017.

Del Poeta M, Chen SF, Von Hoff D, et al. Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells. Antimicrob Agents Chemother. 1999 Dec;43(12):2862-8. PMID: 10582872.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M576486

    Mometasone Furoate

    Synthetic glucocorticoid

    ≥98%
  • K040007

    KB-0742

    CDK9 inhibitor.

    ≥98%
  • G733400

    GSK-2578215A

    Selective inhibitor of LRRK2.

    ≥98%
  • F1655

    Fenoprofen Calcium Dihydrate

    NSAID; COX-1/2 inhibitor.

    ≥97%
  • T3584

    Tivantinib

    MET and GSK-3α/β inhibitor.

    ≥98%
  • A4534

    Aliskiren Hemifumarate

    Renin inhibitor.

    ≥98%
  • M568270

    Mogroside V

    Triterpenoid

    ≥98%
  • D5898

    Doxycycline Monohydrate

    Tetracycline; protein translation inhibitor, MM...

    ≥97%
  • A7461

    Asperosaponin VI

    Triterpene saponin found in Dipsacus asper.

    ≥98%
  • R2917

    Rhein

    Diacerein metabolite, anthraquinone found in Rh...

    ≥88%
  • B5074

    BMS-599626

    EGFR, VEGFR inhibitor.

    ≥98%
  • M9356

    Myomodulin

    Proton pump inhibitor

    ≥95%
  • B1753

    Benfotiamine

    Thiamine/vitamin B derivative, antioxidant.

    ≥98%
  • M1644

    Meloxicam

    NSAID; COX-2 inhibitor.

    ≥98%
  • E6134

    Epimedin C

    Flavonoid found in Epimedium sagittatum.

    ≥98%
  • A2056

    Aflatoxin Q1

    Mycotoxin metabolite

    ≥98%
  • D3227

    Dihydromethysticin

    Kavalactone originally found in Piper methystic...

    ≥97%
  • T3100

    Thyrotropin-releasing Hormone

    Endogenous tripeptide, involved in HPA signalin...

    ≥95%
  • F4881

    Flumequine Sodium

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • B5561

    B-type Natriuretic Peptide (1-32), human

    Endogenous cardiomodulatory peptide; NPR-A agon...

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only