• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Nitidine Chloride

Nitidine Chloride

Product ID N3577
Cas No. 13063-04-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $91.00 In stock
5 mg $145.80 Please Inquire
25 mg $592.50 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Nitidine is a benzophenanthridine alkaloid that exhibits anticancer chemotherapeutic, anti-inflammatory, anti-parasitic, and antifungal properties. In cancer cells, nitidine decreases phosphorylation of Akt and downregulates expression of matrix metalloproteinases 2 and 9 (MMP2/9), inhibiting cellular migration and invasion. In vivo, nitidine inhibits activation of JAK/STAT3, downregulates expression of cyclin D1, cyclin-dependent kinase 4 (CDK4), and Bcl-2, and upregulates expression of p21 and Bax, resulting in decreases in tumor weight and volume. Additionally, nitidine inhibits topoisomerase I and binds to DNA sequences containing alternating G and C base pairs. In macrophages, this compound decreases production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 and inhibits phosphorylation of MAPK and activation of NF-κB. Nitidine also displays inhibitory activity against species of Plasmodium that are resistant to chloroquine and other antimalarial compounds.

Product Info

Cas No.

13063-04-2

Purity

≥98%

Formula

C21H18ClNO4

Formula Wt.

383.82

IUPAC Name

2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride

Solubility

1mg/ml in DMSO

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

N3577 MSDS PDF

Info Sheet

N3577 Info Sheet PDF

References

Fang Z, Tang Y, Jiao W, et al. Nitidine chloride inhibits renal cancer cell metastasis via suppressing AKT signaling pathway. Food Chem Toxicol. 2013 Oct;60:246-51. PMID: 23911800.

Liao J, Xu T, Zheng JX, et al. Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1/STAT3 signaling pathway. Int J Mol Med. 2013 Jul;32(1):79-84. PMID: 23613111.

Wang Z, Jiang W, Zhang Z, et al. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells. J Ethnopharmacol. 2012 Oct 31;144(1):145-50. PMID: 22971898.

Bai LP, Zhao ZZ, Cai Z, et al. DNA-binding affinities and sequence selectivity of quaternary benzophenanthridine alkaloids sanguinarine, chelerythrine, and nitidine. Bioorg Med Chem. 2006 Aug 15;14(16):5439-45. PMID: 16730995.

Nyangulu JM, Hargreaves SL, Sharples SL, et al. Antimalarial benzo[c]phenanthridines. Bioorg Med Chem Lett. 2005 Apr 15;15(8):2007-10. PMID: 15808457.

Li D, Zhao B, Sim SP, et al. 2,3-Dimethoxybenzo[i]phenanthridines: topoisomerase I-targeting anticancer agents. Bioorg Med Chem. 2003 Feb 20;11(4):521-8. PMID: 12538017.

Del Poeta M, Chen SF, Von Hoff D, et al. Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells. Antimicrob Agents Chemother. 1999 Dec;43(12):2862-8. PMID: 10582872.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P7060

    Protocatechuic Acid Ethyl Ester

    Dihydroxyphenolic acid found in cruciferous veg...

    ≥98%
  • D0808

    DCC-2036

    Abl inhibitor.

    ≥98%
  • E6825

    Ergosterol

    Sterol cell membrane component found in yeast a...

    ≥96%
  • A0964

    Adrenocorticotropic Hormone (1-13), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • N1656

    D-(+)-Neopterin

    Endogenous pteridine metabolite of GTP.

    ≥98%
  • P1849

    Pemetrexed Disodium

    Thymidylate synthase inhibitor, potential SHMT,...

    ≥98%
  • T5060

    TMP-269

    HDAC inhibitor.

    ≥98%
  • N7604

    Naltriben

    δ2OR antagonist.

    ≥95%
  • S0168

    Saracatinib

    Src and Abl inhibitor.

    ≥98%
  • O9322

    Oxfendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • P7718

    Pterostilbene

    Stilbene, resveratrol analog.

    ≥98%
  • A0965

    Adrenocorticotropic Hormone (1-14)

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • P8382

    Puupehenone

    Sesquiterpene found in marine sponges.

    ≥94%
  • C2468

    β-Calcitonin Gene Related Peptide, human

    Endogenous calcitonin-family peptide, involved ...

    ≥98%
  • F8272

    Fusarenon X

    Trichothecene mycotoxin produced by Fusarium.

    ≥98%
  • U6858

    Urocortin II, mouse

    Endogenous peptide, involved in stress signalin...

    ≥95%
  • P3269

    Piroxicam

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • P5745

    Polygalic Acid

    Saponin found in Polygala.

    ≥97%
  • C3352

    Cinacalcet Hydrochloride

    Ca2+-sensing receptor agonist.

    ≥99%
  • A686164

    Arecaidine Hydrochloride

    mAChR agonist, selective for M2.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only