LKT Labs

Biochemicals for Life Science Research

Peimine

Peimine

Product ID P1634
Cas No. 23496-41-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $102.00 In stock
10 mg $163.40 In stock
25 mg $302.30 In stock
Bulk Quote

Quicklinks

Description

Peimine is a steroidal alkaloid found in a variety of species of the Fritillaria plant; it exhibits anti-inflammatory activity and acts as an expectorant and anti-tussive in cough medications. Peimine’s anti-tussive activity may result from negative potentiation of transient receptor potential channels TRPV1 and TRPA1 in vitro. Peimine inhibits cough frequency and cough latency in animal models. Additionally, peimine binds the DNA duplex, inhibits production of pro-inflammatory cytokines like TNF-α, IL-6, and IL-1β, and decreases expression of IκB kinase, JNK, and p38.

Product Info

Cas No.

23496-41-5

Purity

≥98%
Formula

C27H45NO3
Formula Wt.

431.65
Chemical Name

(1R,2S,6S,9S,10S,11S,14S,15S,17S,18S,20S,23R,24S)-6,10,23-trimethyl-4-azahexacyclo[12.11.0.02,11.04,9.015,24.018,23]pentacosane-10,17,20-triol
IUPAC Name

(1R,2S,6S,9S,10S,11S,14S,15S,17S,18S,20S,23R,24S)-6,10,23-trimethyl-4-azahexacyclo[12.11.0.02,11.04,9.015,24.018,23]pentacosane-10,17,20-triol
Synonym

Verticine, Wanpeinine A
Appearance

White Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

P1634 MSDS PDF
Info Sheet

P1634 Info Sheet PDF

References

Yi PF, Wu YC, Dong HB, et al. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 2013 Oct;35(5):567-72. PMID: 23944357.

Ma L, Song F, Liu Z, et al. Study on noncovalent complexes of alkaloids with DNA duplex using electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom. 2013 Jan 15;27(1):51-8. PMID: 23239316.

Wang D, Zhu J, Wang S, et al. Antitussive, expectorant and anti-inflammatory alkaloids from Bulbus Fritillariae Cirrhosae. Fitoterapia. 2011 Dec;82(8):1290-4. PMID: 21958967.

Zhang Y, Sreekrishna K, Lin Y, et al. Modulation of transient receptor potential (TRP) channels by Chinese herbal extracts. Phytother Res. 2011 Nov;25(11):1666-70. PMID: 21432926.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • H5748

    D,L-Homocysteine Thiolactone Hydrochloride

    Heterocyclic derivative of cysteine, alters pro...

    ≥99%
  • U8000

    U-74389G

    Antioxidant shown to improve renal function.

    ≥95%
  • B3209

    Bicalutamide

    AR antagonist.

    ≥98%
  • I7556

    1-Isothiocyanato-7-(methylsulfonyl)-heptane

    ITC, erysolin analog.

    ≥98%
  • A4854

    β-Amyloid Peptide (1-42), rat

    Endogenous APP peptide cleavage product, primar...

    ≥95%
  • B1978

    Betulin-3-Acetate

    Pentacyclic triterpene found in various plant s...

    ≥97%
  • P7718

    Pterostilbene

    Stilbene, resveratrol analog.

    ≥98%
  • T2833

    1-Thio-β-D-glucose Tetraacetate

    Imaging agent; Maillard reaction inhibitor.

    ≥98%
  • A0960

    Adrenocorticotropic Hormone (1-39), human

    Endogenous peptide hormone, involved in stress ...

    ≥95%
  • F3354

    Finasteride

    Steroid 5-α-reductase inhibitor.

    ≥98%
  • C3246

    Cilostazol

    Quinoline; PDE 3B inhibitor.

    ≥98%
  • C4000

    CK-636

    Arp2/3 inhibitor.

    ≥98%
  • G1651

    Geniposidic Acid

    Iridoid glucoside found in Eucommia, Castilleja...

    ≥98%
  • D3428

    Dihydrochelerythrine

    Benzophenanthridine alkaloid found in Garcinia....

    ≥98%
  • G2873

    Growth Hormone Releasing Factor, sheep

    Endogenous peptide hormone, involved in growth ...

    ≥95%
  • L1884

    Levosimendan

    Ca2+ sensitizer; ATP-sensitive K+ channel activ...

    ≥98%
  • A9713

    AZD-3514

    Androgen receptor downregulator.

    ≥98%
  • M577521

    Monascorubrin

    Bulgarialactone azaphilone

    ≥98%
  • A5278

    Angiotensin III, human

    Endogenous peptide, cleavage product of AT II; ...

    ≥95%
  • T1677

    Tetracycline

    Polyketide; protein translation inhibitor, mamm...

    ≥90%