• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Pravastatin Lactone

Pravastatin Lactone

Product ID P6800
Cas No. 85956-22-5
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $134.30 In stock
50 mg $401.10 In stock
100 mg $706.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Pravastatin is an inhibitor of HMG-CoA reductase that exhibits anti-hyperlipidemic, anticancer, antithrombotic, antioxidative, immunosuppressive, anti-allergic, and anti-asthma activities. Clinically, pravastatin increases expression of LDL receptors, inducing cellular LDL uptake to decrease levels of LDL and triglycerides and increase levels of HDL. In animal models of cancer, pravastatin increases the efficacy of bevacizumab when given in combination, further decreasing tumor growth and inhibiting angiogenesis and metastasis. Pravastatin inhibits thrombosis in animal models of atherosclerotic plaque rupture and decreases lucigenin-induced O2 radical formation in other in vivo models. Additionally, pravastatin downregulates expression of IL-17 and decreases production of Th2 cytokines and IgE, preventing airway inflammation in animal models of OVA-induced allergies.

Product Info

Cas No.

85956-22-5

Purity

≥98%

Formula

C23H34O6

Formula Wt.

406.51

Chemical Name

(βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid lactone

IUPAC Name

[(1S,3S,7S,8S,8aR)-3-hydroxy-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate

Melting Point

138-142°C

Solubility

Soluble in Chloroform (Sligtly), Dichloromethane (Slightly), Methanol (Slightly). Soliuble in DMSO (25 mg/mL).

Appearance

White

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

P6800 MSDS PDF

Info Sheet

P6800 Info Sheet PDF

Brochures

Statins Flyer

References

Lee SJ, Lee I, Lee J, et al. Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, potentiate the anti-angiogenic effects of bevacizumab by suppressing angiopoietin2, BiP, and Hsp90α in human colorectal cancer. Br J Cancer. 2014 Jun 19. [Epub ahead of print]. PMID: 24945998.

Wu G, Xie Q, Xu L, et al. Pravastatin inhibits plaque rupture and subsequent thrombus formation in atherosclerotic rabbits with hyperlipidemia. Chem Pharm Bull (Tokyo). 2013;61(2):121-4. PMID: 23207681.

Luzak B, Rywaniak J, Stanczyk L, et al. Pravastatin and simvastatin improves acetylsalicylic acid-mediated in vitro blood platelet inhibition. Eur J Clin Invest. 2012 Aug;42(8):864-72. PMID: 22409214.

Kassan M, Montero MJ, Sevilla MA. In vitro antioxidant activity of pravastatin provides vascular protection. Eur J Pharmacol. 2010 Mar 25;630(1-3):107-11. PMID: 20044990.

Imamura M, Okunishi K, Ohtsu H, et al. Pravastatin attenuates allergic airway inflammation by suppressing antigen sensitisation, interleukin 17 production and antigen presentation in the lung. Thorax. 2009 Jan;64(1):44-9. PMID: 18835962.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T1854

    Tenofovir Monohydrate

    Nucleotide analog; RT inhibitor.

    ≥98%
  • T5761

    Topotecan Hydrochloride

    Captothecin derivative; topoisomerase I inhibit...

    ≥97%
  • G3558

    20R-Ginsenoside Rh2

    Triterpene saponin found in Panax.

    ≥98%
  • N3496

    Nizatidine

    Histamine H2 inverse agonist.

    ≥98%
  • T6934

    Trimebutine Maleate

    L-type Ca2+ channel blocker, BK K+ channel modu...

    ≥96%
  • C2844

    Chloramphenicol

    Protein translation inhibitor, peptidyl transfe...

    ≥98%
  • F1650

    Fenbendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • T0092

    1-Hydroxybaccatin I

    Diterpene found in Taxus; potential microtubule...

    ≥98%
  • V3276

    Vitamin E, Natural

    Antioxidant.

    ≥97%
  • A5282

    [Sar1 Ile8]-Angiotensin II

    Peptide, derivative of AT II, involved in vasoc...

    ≥95%
  • I5206

    INCB 28060 Hydrochloride Hydrate

    c-MET inhibitor.

    ≥98%
  • Z1970

    Zerumbone

    Cyclic sesquiterpene found in ginger root; pote...

    ≥99%
  • B4514

    Bleomycin A5 Hydrochloride Cu

    Induces apoptosis, DNA cleavage and strand brea...

    ≥85%
  • G0181

    Gastrin Releasing Peptide, human

    Endogenous bombesin-like peptide, involved in f...

    ≥95%
  • C1869

    Cerulenin

    Found in Cephalosporium; fatty acid synthase in...

    ≥98%
  • A5070

    Angiotensin Acetate

    Peptide, derivative of AT I, cleavage product o...

    ≥95%
  • W0275

    R-(+)-Warfarin Sodium >99%ee

    Coumarin; VKORC1 inhibitor.

    ≥99%
  • L9800

    LY-364947

    ALK5 (activin-like) inhibitor.

    ≥98%
  • C2970

    Chrysophanol

    Anthraquinone found in Rheum.

    ≥98%
  • P1754

    Penciclovir

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only