SB-431542

Name: SB-431542
SKU: S0400
Availability: InStock

Product ID S0400

Cas No. 301836-41-9

Purity ≥98%

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Description

SB-431542 inhibits activin receptor-like kinases ALK4, ALK5, and ALK7; this inhibition leads to inhibition of activin and TGF-β signaling with no downstream effects on ERK, JNK, or MAPK. SB-431542 exhibits anti-angiogenic and anticancer activity. In vitro, SB-431542 inhibits proliferation and motility of glioma cells. This compound also induces maturation of dendritic cells through its inhibition of TGF-β, increasing IL-12 production and increasing cytotoxic activity of immune cells in vitro.

Product Info

Cas No.	301836-41-9
Purity	≥98%
Formula	C₂₂H₁₆N₄O₃
Formula Wt.	384.39
IUPAC Name	4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
Melting Point	244.8°C
Solubility	DMSO 76 mg/mL (197.71 mM) Ethanol 3 mg/mL (7.8 mM) Water Insoluble
Appearance	White to off white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	S0400 MSDS PDF
Info Sheet	S0400 Info Sheet PDF

References

Tanaka H, Shinto O, Yashiro M, et al. Transforming growth factor β signaling inhibitor, SB-431542, induces maturation of dendritic cells and enhances anti-tumor activity. Oncol Rep. 2010 Dec;24(6):1637-43. PMID: 21042762.

Halder SK, Beauchamp RD, Datta PK. A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia. 2005 May;7(5):509-21. PMID: 15967103.

Hjelmeland MD, Hjelmeland AB, Sathornsumetee S, et al. SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility. Mol Cancer Ther. 2004 Jun;3(6):737-45. PMID: 15210860.

Inman GJ, Nicolás FJ, Callahan JF, et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol. 2002 Jul;62(1):65-74. PMID: 12065756.

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SB-431542

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