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Terpinen-4-ol

Terpinen-4-ol

Product ID T1968
Cas No. 562-74-3
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $63.60 In stock
25 g $142.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Terpinen-4-ol is a monoterpene originally found in many plants and is one of the primary active ingredients in tea tree oil. Terpinen-4-ol exhibits anticancer chemotherapeutic, anti-inflammatory, antibacterial, and antifungal activities. In leukemia cells, terpinen-4-ol induces release of cytochrome c and activation of caspase 8, resulting in autophagy, apoptosis, and cell death. In non-small cell lung cancer (NSCLC) cells, terpinen-4-ol induces cleavage of poly(ADP)-ribose polymerase (PARP), activates caspases 3 and 9, decreases mitochondrial membrane potential, increases the Bax/Bcl-2 ratio, and increases levels of p53, resulting in apoptosis and cell death. Additionally, this compound decreases myeloperoxidase activity and expression of MIP-2 and other cytokines in animal models of oral candidiasis. Terpinen-4-ol displays antimicrobial activity against gram positive and gram negative bacteria such as Campylobacter as well as fungi such as Aspergillus and Fusarium.

Product Info

Cas No.

562-74-3

Purity

≥98%

Formula

C10H18O

Formula Wt.

154.25

IUPAC Name

4-methyl-1-propan-2-ylcyclohex-3-en-1-ol

Synonym

Terpineol, 4-Carvomenthenol

Appearance

Colorless to yellowish slightly viscous liquid

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T1968 MSDS PDF

Info Sheet

T1968 Info Sheet PDF

References

Banjerdpongchai R, Khaw-On P. Terpinen-4-ol Induces Autophagic and Apoptotic Cell Death in Human Leukemic HL-60 Cells. Asian Pac J Cancer Prev. 2013;14(12):7537-42. PMID: 24460330.

Kurekci C, Padmanabha J, Bishop-Hurley SL, et al. Antimicrobial activity of essential oils and five terpenoid compounds against Campylobacter jejuni in pure and mixed culture experiments. Int J Food Microbiol. 2013 Sep 16;166(3):450-7. PMID: 24041998.

Ninomiya K, Hayama K, Ishijima SA, et al. Suppression of inflammatory reactions by terpinen-4-ol, a main constituent of tea tree oil, in a murine model of oral candidiasis and its suppressive activity to cytokine production of macrophages in vitro. Biol Pharm Bull. 2013;36(5):838-44. PMID: 23649340.

Morcia C, Malnati M, Terzi V. In vitro antifungal activity of terpinen-4-ol, eugenol, carvone, 1,8-cineole (eucalyptol) and thymol against mycotoxigenic plant pathogens. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2012;29(3):415-22. PMID: 22257275.

Wu CS, Chen YJ, Chen JJ, et al. Terpinen-4-ol Induces Apoptosis in Human Nonsmall Cell Lung Cancer In Vitro and In Vivo. Evid Based Complement Alternat Med. 2012;2012:818261. PMID: 21760828.

Custom Order

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