Tofacitinib Citrate

Name: Tofacitinib Citrate
SKU: T5720
Availability: InStock

Product ID T5720

Cas No. 540737-29-9

Purity ≥99%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Tofacitinib is an inhibitor of JAK1/2/3 that is clinically used to treat myelofibrosis and rheumatoid arthritis. Tofacitinib exhibits immunosuppressive, anti-inflammatory, and antiviral activities. In vitro, tofacitinib inhibits production of inflammatory cytokines, Th2 cell differentiation, Th17 cell differentiation, and activation of STAT1, which in turn prevents induction of T-bet and generation of Th1 cells. In other cellular models, tofacitinib inhibits HIV replication and reactivation of latent HIV-1.

Product Info

Cas No.	540737-29-9
Purity	≥99%
Formula	C₁₆H₂₀N₆O • C₆H₈O₇
Formula Wt.	504.49
Chemical Name	3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile citrate salt
IUPAC Name	2-hydroxypropane-1,2,3-tricarboxylic acid;3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile
Synonym	CP-690550-10, Tasocitinib citrate salt
Solubility	Soluble in DMSO (100 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), DMF (~5 mg/ml), water (<1 mg/ml at 25 °C), and 0.5% methylcellulose (30 mg/ml at 25 °C)
Appearance	White to off white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	T5720 MSDS PDF
Info Sheet	T5720 Info Sheet PDF

References

Gavegnano C, Detorio M, Montero C, et al. Ruxolitinib and Tofacitinib are Potent and Selective Inhibitors of HIV-1 Replication and Virus Reactivation in Vitro. Antimicrob Agents Chemother. 2014 Jan 13. [Epub ahead of print]. PMID: 24419350.

Yamaoka K, Tanaka Y. Targeting the Janus kinases in rheumatoid arthritis: focus on tofacitinib. Expert Opin Pharmacother. 2014 Jan;15(1):103-13. PMID: 4188100.

Tak PP, Kalden JR. Advances in rheumatology: new targeted therapeutics. Arthritis Res Ther. 2011 May 25;13 Suppl 1:S5. PMID: 21624184.

Ghoreschi K, Jesson MI, Li X, et al. Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J Immunol. 2011 Apr 1;186(7):4234-43. PMID: 21383241.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Phone
This field is for validation purposes and should be left unchanged.

Tofacitinib Citrate

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Cisplatin

trans-3,4′,5-Trimethoxy Stilbene

Neurotensin

CV-66

Oxybutynin Hydrochloride

Secretin Acetate

[DPhe7]-Bradykinin

Chlortetracycline Hydrochloride

Deltarasin Hydrochloride Trihydrate

(+)-JQ-1

Cytochalasin C

Salbutamol Free Base

Limonin

Niflumic Acid

Angiotensin I, human

CEP-28122 Mesylate

Etoposide

Ginsenoside Rg3

Azilsartan

Rolipram

Footer