LKT Labs

Biochemicals for Life Science Research

Tofacitinib Citrate

Tofacitinib Citrate

Product ID T5720
Cas No. 540737-29-9
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $115.50 In stock
25 mg $362.30 In stock
100 mg $1,312.50 In stock
Bulk Quote

Quicklinks

Description

Tofacitinib is an inhibitor of JAK1/2/3 that is clinically used to treat myelofibrosis and rheumatoid arthritis. Tofacitinib exhibits immunosuppressive, anti-inflammatory, and antiviral activities. In vitro, tofacitinib inhibits production of inflammatory cytokines, Th2 cell differentiation, Th17 cell differentiation, and activation of STAT1, which in turn prevents induction of T-bet and generation of Th1 cells. In other cellular models, tofacitinib inhibits HIV replication and reactivation of latent HIV-1.

Product Info

Cas No.

540737-29-9
Purity

≥99%
Formula

C16H20N6O • C6H8O7
Formula Wt.

504.49
Chemical Name

3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile citrate salt
IUPAC Name

2-hydroxypropane-1,2,3-tricarboxylic acid;3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile
Synonym

CP-690550-10, Tasocitinib citrate salt
Solubility

Soluble in DMSO (100 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), DMF (~5 mg/ml), water (<1 mg/ml at 25 °C), and 0.5% methylcellulose (30 mg/ml at 25 °C)
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

T5720 MSDS PDF
Info Sheet

T5720 Info Sheet PDF

References

Gavegnano C, Detorio M, Montero C, et al. Ruxolitinib and Tofacitinib are Potent and Selective Inhibitors of HIV-1 Replication and Virus Reactivation in Vitro. Antimicrob Agents Chemother. 2014 Jan 13. [Epub ahead of print]. PMID: 24419350.

Yamaoka K, Tanaka Y. Targeting the Janus kinases in rheumatoid arthritis: focus on tofacitinib. Expert Opin Pharmacother. 2014 Jan;15(1):103-13. PMID: 4188100.

Tak PP, Kalden JR. Advances in rheumatology: new targeted therapeutics. Arthritis Res Ther. 2011 May 25;13 Suppl 1:S5. PMID: 21624184.

Ghoreschi K, Jesson MI, Li X, et al. Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J Immunol. 2011 Apr 1;186(7):4234-43. PMID: 21383241.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A4606

    Albendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥95%
  • D5610

    Docosahexaenoic Acid (all cis-4,7,10,13,16,19)

    Essential fatty acid found in fish oil, involve...

    ≥98%
  • M5753

    Monensin Sodium

    Polyether ionophore, autophagy inhibitor.

    ≥98%
  • E7230

    Ethambutol Dihydrochloride

    Arabinosyl transferase inhibitor.

    ≥98%
  • P8270

    Purvalanol A

    Purine derivative; CDK inhibitor.

    ≥98%
  • D017538

    Danoprevir

    May be useful against COVID-19

    ≥98%
  • N0205

    Nabumetone

    1-Naphthalenacetic acid derivative, NSAID; COX-...

    ≥98%
  • G1869

    Geranylgeraniol

    Diterpene alcohol, geranylgeranyl pyrophosphate...

    ≥85%
  • H3273

    Histatin 5

    Endogenous antimicrobial peptide, binds bacteri...

    ≥95%
  • C1624

    Cefuroxime Sodium

    β-lactam; penicillin binding protein inhibitor...

    ≥98%
  • T1754

    Tenatoprazole

    H+/K+ ATPase inhibitor.

    ≥98%
  • E543721

    Ensartinib

    A third-generation ALK inhibitor.

    ≥98%
  • P4782

    PluriSIn 1

    Stearoyl-coA desaturase 1 inhibitor.

    ≥98%
  • V0269

    Vardenafil Dihydrochloride

    PDE5 inhibitor.

    ≥99%
  • G3457

    Ginsenoside Re

    Triterpene saponin found in species of Panax; P...

    ≥98%
  • G5216

    GNE-7915

    LRRK2 inhibitor.

    ≥98%
  • F3206

    Fibrinolysis Inhibiting Factor

    Peptide; fibrinolysis inhibitor.

    ≥98%
  • K9858

    Kyotorphin

    Opioid neuropeptide; kyotorphin agonist.

    ≥95%
  • P327211

    Pifithrin-α Hydrobromide

    p53 inhibitor

    ≥98%
  • B030966

    BAY 11-7082

    inhibits inflammatory signaling

    ≥98%