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Trandolapril

Trandolapril

Product ID T6803
Cas No. 87679-37-6
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $131.40 In stock
100 mg $428.50 In stock
250 mg $820.40 In stock
500 mg $1,358.10 In stock
Bulk Quote

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  • Description
  • Product Info
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  • References
  • Description
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Description

Trandolapril is an inhibitor of angiotensin-converting enzyme (ACE) that is used to treat congestive heart failure (CHF). Trandolapril exhibits antihypertensive, neuroprotective, and cardioprotective activities. Trandolapril inhibits expression of matrix metalloproteinases 2 and 9 (MMP2/MMP9) in a middle cerebral artery occlusion model of cerebral ischemia. In other animal models, trandolapril decreases myocardial bradykinin and eNOS expression in aortic endothelium and cardiac myocytes. Additionally, this compound prevents left ventricular pressure changes and hypertrophy associated with CHF and myocardial infarction. Trandolapril attenuates cardiac dysfunction induced by heart failure, decreasing mean arterial pressure (MAP) and left ventricular systolic pressure and also minimizing heart failure-induced decreases in cardiac output and stroke volume.

Product Info

Cas No.

87679-37-6

Purity

≥98%

Formula

C24H34N2O5

Formula Wt.

430.54

Chemical Name

(2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid

IUPAC Name

(2S,3aR, 7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl] -2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid

Synonym

Mavik, Gopten, Odrik

Melting Point

119-123°C

Solubility

Soluble in methanol, dichloromethane, DMSO, and ethanol

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T6803 MSDS PDF

Info Sheet

T6803 Info Sheet PDF

References

Tanaka H, Takai S, Jin D, et al. Inhibition of matrix metalloproteinase-9 activity by trandolapril after middle cerebral artery occlusion in rats. Hypertens Res. 2007 May;30(5):469-75. PMID: 17587759.

Toyoshima H, Nasa Y, Kohsaka Y, et al. The effect of chronic treatment with trandolapril on cyclic AMP-and cyclic GMP-dependent relaxations in aortic segments of rats with chronic heart failure. Br J Pharmacol. 1998 Jan;123(2):344-52. PMID: 9489624.

Sanbe A, Tanonaka K, Kobayasi R, et al. Effects of long-term therapy with ACE inhibitors, captopril, enalapril and trandolapril, on myocardial energy metabolism in rats with heart failure following myocardial infarction. J Mol Cell Cardiol. 1995 Oct;27(10):2209-22. PMID: 8576937.

Custom Order

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