• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Vatalanib Dihydrochloride

Vatalanib Dihydrochloride

Product ID V0376
Cas No. 212141-51-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $58.50 In stock
5 mg $97.30 In stock
10 mg $127.20 In stock
25 mg $194.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Vatalanib is an inhibitor of VEGFR that is currently in clinical trials for the treatment of myelodysplastic syndrome, lymphomas, non-small cell lung cancers (NSCLCs), and other cancers. Vatalanib exhibits anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and analgesic activities. In animal models with mammary carcinoma allografts, vatalanib decreases tumor vascularization. In animal models of pancreatic carcinoma, vatalanib inhibits tumor growth and metastasis and decreases microvessel density. Additionally, vatalanib decreases chronic neuropathic pain in animal models of chronic constriction injury, as inhibition of VEGFR2 inhibits signaling through neuropathic pain-mediating P2X (2/3) receptors.

Product Info

Cas No.

212141-51-0

Purity

≥98%

Formula

C20H15ClN4 • 2HCl

Formula Wt.

419.73

IUPAC Name

N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine;dihydrochloride

Synonym

PTK-787 Dihydrochloride, PTK 787 Dihydrochloride, PTK787 Dihydrochloride, ZK-222584 Dihydrochloride, ZK 222584 Dihydrochloride, ZK222584 Dihydrochloride, CGP-797870 Dihydrochloride, ZK232934 Dihydrochloride

Melting Point

268-270°C

Appearance

Off-white to pinkish powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

V0376 MSDS PDF

Info Sheet

V0376 Info Sheet PDF

References

Gupta P, Mulkey F, Hasserjian RP, et al. A phase II study of the oral VEGF receptor tyrosine kinase inhibitor vatalanib (PTK787/ZK222584) in myelodysplastic syndrome: Cancer and Leukemia Group B study 10105 (Alliance). Invest New Drugs. 2013 Oct;31(5):1311-20. PMID: 23700288.

Liu S, Xu C, Li G, et al. Vatalanib decrease the positive interaction of VEGF receptor-2 and P2X2/3 receptor in chronic constriction injury rats. Neurochem Int. 2012 May;60(6):565-72. PMID: 22361062.

Gauler TC, Besse B, Mauguen A, et al. Phase II trial of PTK787/ZK 222584 (vatalanib) administered orally once-daily or in two divided daily doses as second-line monotherapy in relapsed or progressing patients with stage IIIB/IV non-small-cell lung cancer (NSCLC). Ann Oncol. 2012 Mar;23(3):678-87. PMID: 21617019.

Hlushchuk R, Riesterer O, Baum O, et al. Tumor recovery by angiogenic switch from sprouting to intussusceptive angiogenesis after treatment with PTK787/ZK222584 or ionizing radiation. Am J Pathol. 2008 Oct;173(4):1173-85. PMID: 18787105.

Solorzano CC, Baker CH, Bruns CJ, et al. Inhibition of growth and metastasis of human pancreatic cancer growing in nude mice by PTK 787/ZK222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases. Cancer Biother Radiopharm. 2001 Oct;16(5):359-70. PMID: 11776753.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P3198

    Phytanic Acid

    Fatty acid metabolite of chlorophyll; RXR and P...

    ≥97%
  • E7858

    Etoricoxib

    NSAID; COX-2 inhibitor.

    ≥99%
  • Q8139

    Quizartinib

    FLT3, c-Kit, PDGFR inhibitor.

    ≥98%
  • A4606

    Albendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥95%
  • G1658

    Gentamycin Sulfate

    Aminoglycoside; protein translation inhibitor.<...

  • P7058

    Protocatechuic Aldehyde

    Polyphenol found in various plants and foods.

    ≥98%
  • T0094

    2′,7-Bisacetyltaxol

    Taxane synthesis intermediate.

    ≥96%
  • M1779

    Methyldopa Sesquihydrate

    DOPA decarboxylase inhibitor, indirect α2-adre...

    ≥98%
  • E6814

    Erdosteine

    Thiol derivative, antioxidant.

    ≥98%
  • V0369

    Varenicline Tartrate

    α7 and β4 nAChR agonist, α4β2 and α6β2 nA...

    ≥99%
  • A9713

    AZD-3514

    Androgen receptor downregulator.

    ≥98%
  • E5057

    Emodin

    Anthraquinone found in various plant sources; C...

    ≥95%
  • A7577

    Astilbin

    Flavonoid found in various plant sources.

    ≥99%
  • T0077

    Transactivator of Transcription Peptide (2-4)

    Peptide, contains two cell-penetrating sequence...

    ≥95%
  • V9228

    VX-765

    NLRP3 and caspase-1 inhibitor.

    ≥98%
  • M1669

    6-Mercaptopurine Monohydrate

    Thiopurine antimetabolite; PRPP amidotransferas...

    ≥98%
  • A464768

    Altertoxin 1

    Mycotoxin contaminant in food and feed.

    ≥97%
  • A7618

    Atenolol

    β1-adrenergic antagonist.

    ≥98%
  • T1953

    Tenovin-3

    Potential p53 activator or SIRT2 inhibitor.

    ≥98%
  • C5645

    Colchicine

    Found in Colchicum; microtubule polymerization ...

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only