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Veratramine is a steroidal alkaloid found in species of Veratrum and Fritillaria. Veratramine inhibits the hedgehog signaling pathway in vitro, indicating potential anticancer chemotherapeutic benefit. Veratramine also exhibits neuromodulatory and antihypertensive activities. In frontal cortex slices, veratramine evokes release of 5-HT and also inhibits reuptake of 5-HT. In hypertensive rats, oral veratramine decreases blood pressure.
| Cas No. | 60-70-8 |
|---|---|
| Purity | ≥98% |
| Formula | C27H39NO2 |
| Formula Wt. | 409.60 |
| Chemical Name | 2-[1-(3-hydroxy-10,11b-dimethyl-1,2,3,4,6,6a,11,11a-octahydrobenzo[a]fluoren-9-yl)ethyl]-5-methylpiperidin-3-ol |
| IUPAC Name | (2S,3R,5S)-2-[(1S)-1-[(3S,6aR,11aS,11bR)-3-hydroxy-10,11b-dimethyl-1,2, 3,4,6,6a,11, 11a-octahydrobenzo[a]fluoren-9-yl]ethyl]-5-methylpiperidin-3-ol |
| Melting Point | 206-208C |
| Solubility | Soluble in Ethanol and Methanol |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
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| Info Sheet | |
| Brochures |
Tang J, Li HL, Shen YH, et al. Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum. Phytother Res. 2010 Jun;24(6):821-6. PMID: 20013819.
Wang L, Li W, Liu Y. Hypotensive effect and toxicology of total alkaloids and veratramine from roots and rhizomes of Veratrum nigrum L. in spontaneously hypertensive rats. Pharmazie. 2008 Aug;63(8):606-10. PMID: 18771011.
Nagata R, Izumi K. Veratramine-induced behavior associated with serotonergic hyperfunction in mice. Jpn J Pharmacol. 1991 Jan;55(1):129-37. PMID: 1710297.