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Veratramine

Veratramine

Product ID V1868
Cas No. 60-70-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $77.70 In stock
5 mg $102.00 In stock
25 mg $204.30 In stock
100 mg $540.80 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Veratramine is a steroidal alkaloid found in species of Veratrum and Fritillaria. Veratramine inhibits the hedgehog signaling pathway in vitro, indicating potential anticancer chemotherapeutic benefit. Veratramine also exhibits neuromodulatory and antihypertensive activities. In frontal cortex slices, veratramine evokes release of 5-HT and also inhibits reuptake of 5-HT. In hypertensive rats, oral veratramine decreases blood pressure.

Product Info

Cas No.

60-70-8

Purity

≥98%

Formula

C27H39NO2

Formula Wt.

409.60

Chemical Name

2-[1-(3-hydroxy-10,11b-dimethyl-1,2,3,4,6,6a,11,11a-octahydrobenzo[a]fluoren-9-yl)ethyl]-5-methylpiperidin-3-ol

IUPAC Name

(2S,3R,5S)-2-[(1S)-1-[(3S,6aR,11aS,11bR)-3-hydroxy-10,11b-dimethyl-1,2, 3,4,6,6a,11, 11a-octahydrobenzo[a]fluoren-9-yl]ethyl]-5-methylpiperidin-3-ol

Melting Point

206-208C

Solubility

Soluble in Ethanol and Methanol

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

V1868 MSDS PDF

Info Sheet

V1868 Info Sheet PDF

Brochures

Hedgehog Signaling Flyer

References

Tang J, Li HL, Shen YH, et al. Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum. Phytother Res. 2010 Jun;24(6):821-6. PMID: 20013819.

Wang L, Li W, Liu Y. Hypotensive effect and toxicology of total alkaloids and veratramine from roots and rhizomes of Veratrum nigrum L. in spontaneously hypertensive rats. Pharmazie. 2008 Aug;63(8):606-10. PMID: 18771011.

Nagata R, Izumi K. Veratramine-induced behavior associated with serotonergic hyperfunction in mice. Jpn J Pharmacol. 1991 Jan;55(1):129-37. PMID: 1710297.

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