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Astilbin

Astilbin

Product ID A7577
Cas No. 29838-67-3
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $112.20 In stock
10 mg $173.70 In stock
25 mg $306.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Astilbin is a flavonoid found in several plants, including species of Engelhardia and Smilax. Astilbin displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities. In vitro, astilbin inhibits expression of IL-1β, IL-6, IL-10, MCP-1, and TNF-α, as well as activity of horseradish peroxidase and myeloperoxidase. This compound also inhibits maturation of and antigen presentation by dendritic cells and activation and proliferation of T cells. Astilbin downregulates NF-κB and c-Myc and induces cell cycle arrest and caspase-mediated apoptosis in hepatoma cells. Additionally, astilbin also inhibits release of prostaglandin E2.

Product Info

Cas No.

29838-67-3

Purity

≥99%

Formula

C21H22O11

Formula Wt.

450.39

Chemical Name

5,7,3',4'-tetrahydroxy-2,3-dihydroflavonol-3-ß-o-rhamnoside

IUPAC Name

(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4, 5-trihydroxy-6-methyloxan-2-yl]oxy-2,3-dihydrochromen-4-one

Synonym

Astibin, Isoastilbin, Taxifolin 3-O-rhamnoside, Neoisoastilbin

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A7577 MSDS PDF

Info Sheet

A7577 Info Sheet PDF

References

Li P, Gao S, Jie W, et al. Astilbin inhibits proliferation of rat aortic smooth muscle cells induced by angiotensin II and down-regulates expression of protooncogene. J Huazhong Univ Sci Technolog Med Sci. 2012 Apr;32(2):181-5. PMID: 22528217.

Huang H, Cheng Z, Shi H, et al. Isolation and characterization of two flavonoids, engeletin and astilbin, from the leaves of Engelhardia roxburghiana and their potential anti-inflammatory properties. J Agric Food Chem. 2011 May 11;59(9):4562-9. PMID: 21476602.

Petacci F, Freitas SS, Brunetti IL, et al. Inhibition of peroxidase activity and scavenging of reactive oxygen species by astilbin isolated from Dimorphandra mollis (Fabaceae, Caesalpinioideae). Biol Res. 2010;43(1):63-74. PMID: 21157633.

Zou S, Shen X, Tang Y, et al. Astilbin suppresses acute heart allograft rejection by inhibiting maturation and function of dendritic cells in mice. Transplant Proc. 2010 Nov;42(9):3798-802. PMID: 21094859.

Lucas-Filho MD, Silva GC, Cortes SF, et al. ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz. Phytomedicine. 2010 Apr;17(5):383-7. PMID: 19879122.

Sa F, Gao JL, Fung KP, et al. Anti-proliferative and pro-apoptotic effect of Smilax glabra Roxb. extract on hepatoma cell lines. Chem Biol Interact. 2008 Jan 10;171(1):1-14. PMID: 17996228.

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