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Bosutinib, structural isomer

Bosutinib, structural isomer

Product ID B5875
Cas No. 1391063-17-4
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $78.80 In stock
25 mg $152.30 In stock
100 mg $441.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

The bosutinib structural isomer differs from bosutinib itself only in the positions of the chlorine and methoxy substituents on the aniline ring. Bosutinib is an anticancer chemotherapeutic compound that inhibits src and Abl kinases and is clinically used to treat chronic myeloid leukemia. In vivo, bosutinib does not induce apoptosis but does decrease cell proliferation, inhibit cell differentiation, and inhibit tumor metastases, all likely through inhibition of downstream MAPK signaling. Additionally, bosutinib may alter IGF-1 and IGF binding protein 3 (IGF bp3) signaling as well. This compound also shows neuroprotective and cognition enhancing benefits in animal models of Alzheimer’s disease. Bosutinib clears β-amyloid plaques and increases cognitive function by facilitation interaction between parkin and Beclin-1 proteins, which then accumulate in the lysosome for degradation.

Product Info

Cas No.

1391063-17-4

Purity

≥98%

Formula

C26H29Cl2N5O3

Formula Wt.

530.45

Chemical Name

4-(3,5-Dichloro-4-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile

IUPAC Name

4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile

Melting Point

210-221°C

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

B5875 MSDS PDF

Info Sheet

B5875 Info Sheet PDF

References

Rassi FE, Khoury HJ. Bosutinib: a SRC-ABL tyrosine kinase inhibitor for treatment of chronic myeloid leukemia. Pharmgenomics Pers Med. 2013 Aug 5;6:57-62. PMID: 24019749.

Lonskaya I, Hebron ML, Desforges NM, et al. Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance. EMBO Mol Med. 2013 Aug;5(8):1247-62. PMID: 23737459.

Ulmer A, Tabea Tauer J, Glauche I, et al. TK inhibitor treatment disrupts growth hormone axis: clinical observations in children with CML and experimental data from a juvenile animal model. Klin Padiatr. 2013 May;225(3):120-6. PMID: 23716272.

Amsberg GK, Schafhausen P. Bosutinib in the management of chronic myelogenous leukemia. Biologics. 2013;7:115-22. PMID: 23674887.

Kim WG, Guigon CJ, Fozzatti L, et al. SKI-606, an Src inhibitor, reduces tumor growth, invasion, and distant metastasis in a mouse model of thyroid cancer. Clin Cancer Res. 2012 Mar 1;18(5):1281-90. PMID: 22271876.

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